远志的化学成分及防治阿尔兹海默症的研究进展

李旭冉, 陈思邈, 陈伟燕, 宋精梅, 张宇燕

中国药学杂志 ›› 2022, Vol. 57 ›› Issue (1) : 15-23.

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中国药学杂志 ›› 2022, Vol. 57 ›› Issue (1) : 15-23. DOI: 10.11669/cpj.2022.01.003
综述

远志的化学成分及防治阿尔兹海默症的研究进展

  • 李旭冉, 陈思邈, 陈伟燕, 宋精梅, 张宇燕*
作者信息 +

Research Progress on Chemical Constituents of Polygala tenuifolia and Prevention and Treatment of Alzheimer's Disease

  • LI Xu-ran, CHEN Si-miao, CHEN Wei-yan, SONG Jing-mei, ZHANG Yu-yan*
Author information +
文章历史 +

摘要

远志是中国传统医学上用于改善记忆和认知功能的药物,具有安神益智,解郁等功效。远志中主要含有三萜皂苷类、酮类、寡糖酯类等多种化合物。远志及其组分具有抗β淀粉样蛋白、调节Tau蛋白、抗炎、抗氧化、抗细胞凋亡等作用。能多途径、多靶点抑制脑神经元的退行性发展,有效防治阿尔兹海默症。本文就远志的化学成分及组分防治阿尔兹海默症的研究进展进行综述,有助于远志的综合开发利用。探讨远志及组分防治阿尔兹海默症的作用机制,筛选寻找潜在治疗阿尔兹海默症等神经退行性疾病的药物成分,有助于指导临床在提高认知,改善记忆能力等方面的配伍应用。

Abstract

Polygala tenuifolia, a traditional Chinese medicine, containing triterpenoid saponins, xanthones, oligosaccharide esters and other compounds, has been used to improve memory and cognitive function for more than 2000 years with the effects of tranquilizing mind, improving intelligence and relieving depression. Polygala tenuifolia and its components have the effects anti-amyloid β-protein, regulating Tau protein, anti-inflammation, anti-oxidation, anti-apoptosis and so on. It can inhibit the degenerative development of brain neurons in multiple ways and targets, and effectively prevent and treat Alzheimer's disease. This review summarizes the chemical constituents of Polygala tenuifolia and the research progress of its components in the prevention and treatment of Alzheimer's disease, which is helpful for the comprehensive development and utilization of Polygala tenuifolia. This review will attempt to explore the mechanism of polygala tenuifolia and its components in preventing and treating Alzheimer's disease, and to screen and search for potential drug components in the treatment of Alzheimer's disease and other neurodegenerative diseases, which will help to guide the clinical application of compatibility in improving cognition and memory ability.

关键词

远志 / 化学成分 / 阿尔兹海默症 / 安神 / 益智

Key words

Polygala tenuifolia / chemical constituents / Alzheimer's disease / tranquilizing mind / improving intelligence

引用本文

导出引用
李旭冉, 陈思邈, 陈伟燕, 宋精梅, 张宇燕. 远志的化学成分及防治阿尔兹海默症的研究进展[J]. 中国药学杂志, 2022, 57(1): 15-23 https://doi.org/10.11669/cpj.2022.01.003
LI Xu-ran, CHEN Si-miao, CHEN Wei-yan, SONG Jing-mei, ZHANG Yu-yan. Research Progress on Chemical Constituents of Polygala tenuifolia and Prevention and Treatment of Alzheimer's Disease[J]. Chinese Pharmaceutical Journal, 2022, 57(1): 15-23 https://doi.org/10.11669/cpj.2022.01.003
中图分类号: R284   

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基金

国家自然科学基金项目资助(81774230);浙江省自然科学基金项目资助(LY21H270012)
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